Advances in Occlusion Myocardial Infarction Detection (Mayo Clinic Cardiovascular CME Podcast, by Dr. Anthony Kashou)
In this Mayo Clinic Cardiovascular CME episode, Dr. Pendell Meyers explains how the Queen of Hearts™ AI is helping drive the shift from STEMI/NSTEMI to OMI vs non-OMI. Validated across thousands of patients, the AI model doubled sensitivity compared to STEMI criteria, enabling earlier and more accurate detection of occlusions — and laying the groundwork for a new era in acute MI care.
About the Podcast
The Mayo Clinic Cardiovascular CME Podcast brings leading experts together to discuss the latest advances in cardiology, from foundational concepts to cutting-edge innovations. Hosted by Dr. Anthony H. Kashou, the show provides clinicians with practical insights that can directly improve patient care.
Summary of the Episode
In this episode, Dr. Kashou speaks with Dr. Pendell Meyers (Atrium Health, co-editor of Dr. Smith’s ECG Blog) about the paradigm shift from STEMI/NSTEMI to OMI vs non-OMI and the role of artificial intelligence in making this transition possible.
- Why OMI matters: Many NSTEMI patients actually have occluded arteries, which leads to delayed or missed interventions and higher mortality.
- Queen of Hearts™ AI model: Trained on >18,000 ECGs, it can analyze both digital ECG files and even bedside smartphone photos, predicting OMI with high accuracy.
- Validation results: In a multicenter study of 2,263 patients, Queen of Hearts achieved 83% sensitivity and 93% specificity, far outperforming STEMI criteria (34% sensitivity). Accuracy matched expert human interpreters (~91%).
- False positives vs STEMI criteria: While Queen of Hearts had more “false positives” by strict definitions, many of these patients still had meaningful disease — including acute MI requiring PCI — making them clinically valuable activations.
- Next steps: Ongoing external validations, FDA submission, and the design of randomized controlled trials to prove patient-centered benefits of the OMI paradigm.
“Queen of Hearts achieved double the sensitivity of STEMI criteria and perfect interrater reliability — meaning anyone, anywhere, can apply it with expert-level accuracy.”— Dr. Pendell Meyers, Mayo Clinic Cardiovascular CME
🎧 Listen to the episode: Official page
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About PMcardio
PMcardio is a CE-marked Class IIb AI medical device that interprets any 12-lead ECG — from a photo or a digital file — in seconds. It detects 50+ ECG findings, including occlusion myocardial infarction (OMI) — the acute coronary occlusions that conventional STEMI criteria miss in over half of cases. Its Queen of Hearts™ OMI model holds FDA Breakthrough Device Designation, and PMcardio is already used by 100,000+ clinicians who have analyzed more than 2.5 million ECGs.
About Powerful Medical
Powerful Medical is a medical-technology company using artificial intelligence to transform how cardiovascular disease — the world’s leading cause of death — is diagnosed. Founded in 2017, it built PMcardio, the world’s first AI medical device to detect acute coronary occlusion (OMI) from an ECG. Its research is published in the European Heart Journal – Digital Health and validated across 25+ clinical studies, and its Queen of Hearts™ model earned FDA Breakthrough Device Designation. To date, PMcardio has supported the detection of 120,000+ heart attacks across 150+ hospital deployments worldwide.
