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Powerful Medical
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11. October 2025
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1 min to read
  • Study

Electrocardiographic Diagnostic Possibilities for Atrial Fibrillation Using Artificial Intelligence: Differentiation from Sinus Rhythm and Other Arrhythmias with the Pmcardio App in Covid-19 Patients

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Overview


This study evaluated how effectively artificial intelligence can detect atrial fibrillation (AF) in COVID-19 patients using ECG analysis. Researchers compared the PMcardio AI application’s performance with that of cardiologists and infectious disease specialists. Among 116 hospitalized COVID-19 patients, PMcardio achieved perfect diagnostic accuracy (sensitivity and specificity of 1.00) for AF detection, matching cardiologists and surpassing infectious disease specialists. The AI’s performance remained consistent across confidence levels, and its severity assessments correlated significantly with rhythm findings. These results highlight AI’s potential to improve arrhythmia detection, streamline care, and reduce unnecessary in-person evaluations during infectious disease outbreaks.

Published in: Journal of Electrocardiology
Published on: 10 May 2025

Background

Artificial intelligence (AI) has shown potential in enhancing ECG analysis, but its accuracy in detecting atrial fibrillation (AF) in COVID-19 patients remains unstudied. Given the increased risk of arrhythmias and thromboembolic events in this population, AI could aid in timely correct diagnosis, reduce unnecessary consultations, tests, and minimize infection spread. This study evaluated the diagnostic performance of the AI-based PMcardio application in detecting AF in COVID-19 patients.

Methods

The study analyzed 116 hospitalized COVID-19 consecutive patients using paper-based medical records, with a particular focus on ECGs. The presence and type of arrhythmias were determined by an experienced cardiologist and compared with assessments by the infectious disease specialists collected from patient medical records and the PMcardio application.

Results

The mean patient age was 63.28 (14.980) years. The PMcardio AI application demonstrated perfect diagnostic performance, achieving a sensitivity and specificity of 1.00 for AF detection compared to cardiologist’s evaluations. Infectious disease specialists showed lower sensitivity (0.85) but retained high specificity (0.97). No significant association was found between the AI confidence score and diagnostic accuracy (p = 0.660), indicating consistent performance across confidence levels. Additionally, the AI’s severity classification correlated significantly with rhythm diagnoses (p < 0.001).

Conclusion

AI-powered ECG analysis using PMcardio highly accurately detected AF in COVID-19 patients, outperforming infectious disease specialists and matching cardiologist’s accuracy. The integration of AI in clinical practice may enhance arrhythmia detection and streamline diagnostic workflows, particularly in resource-limited and infectious disease settings.

Authors: Rita Vainoryte, Jonas Jucevicius, Edis Baubonis, Albinas Naudziunas, Andrius Alisauskas, Egle Kalinauskiene 

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Powerful Medical leads one of the most important shifts in modern medicine by augmenting human-made clinical decisions with artificial intelligence. Our primary focus is on cardiovascular diseases, the world’s leading cause of death.

About PMcardio

PMcardio is a CE-certified AI that reads ECGs and offers a complex assessment of 49 cardiac conditions. Clinically validated in 15+ studies and trusted by over 100,000 clinicians, it delivers rapid, expert‑level interpretations, empowering emergency physicians, GPs, nurses, paramedics, and cardiologists to act with confidence at the point of care. Available for Individuals and Organizations.

About Powerful Medical

Established in 2017, Powerful Medical has embarked on a mission to revolutionize the diagnosis and treatment of cardiovascular diseases. We are a medical company backed by 28 world-class cardiologists and led by our expert Scientific Board with decades of experience in daily patient care, clinical research, and medical devices. The results of our research are implemented, developed, certified, and brought to market by our 50+ strong interdisciplinary team of physicians, data scientists, AI experts, software engineers, regulatory specialists, and commercial teams.

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Powerful Medical, Inc. | PMcardio and the PMcardio logo are registered trademarks of Powerful Medical. Additionally, Queen of Hearts is claimed as a trademark of Powerful Medical.

 

PMcardio is CE-marked as class IIb medical device under EU MDR and only certified for marketing in the European Union and the United Kingdom. PMcardio technology has not yet been cleared by the US Food and Drug Administration (FDA) for marketing in the USA. Not all modules of the PMcardio platform may be available in your region.

Prior to use, reference the Instructions for Use, for more detailed information on Indications, Contraindications, Warnings, Precautions and Adverse Events.

PMcardio is CE-marked as class IIb medical device under EU MDR and only certified for marketing in the European Union and the United Kingdom. PMcardio technology has not yet been cleared by the US Food and Drug Administration (FDA) for marketing in the USA. Not all modules of the PMcardio platform may be available in your region. Prior to use, reference the Instructions for Use, for more detailed information on Indications, Contraindications, Warnings, Precautions and Adverse Events.

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