PMcardio receives FDA Breakthrough Device Designation — read the full story
Powerful Medical
7. June 2025

May Highlights from Powerful Medical: PMcardio 3.0 Launch, STEMI Research, and Clinical Breakthroughs

Collage showing a conference speaker, PMcardio app UI, hospital partnerships across Europe, and a research award ceremony.

May was a month of meaningful clinical progress and continued product innovation. From major study milestones to impactful conference presentations and pivotal product developments, here are some key highlights from the past few weeks.

Launching PMcardio for Individuals 3.0

We launched PMcardio 3.0, a major upgrade to our AI-powered ECG interpretation platform. Designed to support clinicians in acute care settings, this version delivers faster, explainable diagnostics for STEMI and STEMI-equivalents anytime, anywhere.

Key Improvements in PMcardio 3.0:
Queen of Hearts™: Detects both typical and atypical occlusive MIs with high precision
ECGxplain™: Visual heatmaps clarify the AI’s reasoning for each ECG interpretation
Automated ECG digitization: Reads ECGs from photos, printouts, or screenshots in seconds
Robust clinical performance: Independently confirmed in 19 international studies for early OMI detection

The update also enhances core features, including an extended monthly ECG analysis quota, diagnostic insights, full ECG history, and case complexity indicators to further streamline and support confident clinical decision-making.

Click here to try PMcardio 3.0 today.

Smartphone showing PMcardio for Individuals app interface with ECG heatmaps and AI insights.

New AI ECG Model Presented at EuroPCR

At this year’s EuroPCR, our Chief Medical Officer, Dr. Robert Herman, PhD, presented the feasibility of a new AI ECG model in development focusing on detecting the infarct-related artery (IRA). 

The model demonstrated the ability to accurately predict the IRA even in cases that fall outside conventional STEMI criteria. Procedural and prognostic implications of this model will be evaluated in future studies.

Dr. Robert Herman presenting ECG model feasibility results at EuroPCR, with a slide on IRA detection beyond STEMI criteria.

All AI ECG TIMI Study Sites Now Active

The AI-ECG TIMI Study, a novel, international, multi-center study aimed at validating the use of AI to improve the detection and management of acute coronary syndromes (ACS), has reached a key operational milestone with all nine participating centers now fully active across Austria, Germany, and Switzerland. The final two Austrian centers, LKH Graz II – Standort West and LKH Hochsteiermark Standort-Bruck, recently received ethics approval, enabling full-scale patient enrollment across the entire network and progressing toward a goal of over 700 enrolled patients. 

The next phase will focus on harmonizing data across the international centers and generating real-world evidence to validate AI-powered ECG interpretation in the diagnosis of acute coronary syndromes.

For a full study overview and more details, click here.

Map of Europe showing collaborating clinical sites for PMcardio’s STEMI AI research and Queen of Hearts™ validation.

Queen of Hearts™ Recognized at DGK Early Career Investigator Competition

At this year’s DGK Congress, Dr. Sascha Macherey-Meyer from University Hospital Cologne earned an impressive second place in the DGK Early Career Investigator Competition for his presentation on new findings from the evaluation of the latest Queen of Hearts™ PMcardio AI ECG model. His submission builds on last year’s study evaluating our original Queen of Hearts™ model, further validating the impact of AI in detecting acute coronary syndromes.

During the congress, we also partnered with prof. Dr. Benjamin Meder and Dr. Ali Amr from the University Hospital Heidelberg for a live ECG quiz, “Test the Cardiologists Against AI”, comparing expert interpretation with real-time results from PMcardio—bringing clinical engagement and innovation to the spotlight.

Award ceremony photo with Dr. Sascha Macherey-Meyer holding a certificate, recognized for Queen of Hearts™ study at DGK.
Second left: award winner Dr. Sascha Macherey-Meyer, University Hospital Cologne

With every study and product milestone, we move one step closer to better outcomes in acute cardiac care.

Powerful Medical

Powerful Medical leads one of the most important shifts in modern medicine by augmenting human-made clinical decisions with artificial intelligence. Our primary focus is on cardiovascular diseases, the world’s leading cause of death.
Powerful Medical leads one of the most important shifts in modern medicine by augmenting human-made clinical decisions with artificial intelligence. Our primary focus is on cardiovascular diseases, the world’s leading cause of death.
About PMcardio:

PMcardio is a CE-certified AI that reads ECGs and offers a complex assessment of 49 cardiac conditions. Clinically validated in 15+ studies and trusted by over 100,000 clinicians, it delivers rapid, expert‑level interpretations, empowering emergency physicians, GPs, nurses, paramedics, and cardiologists to act with confidence at the point of care. Available for Individuals and Organizations.

About Powerful Medical:

Established in 2017, Powerful Medical has embarked on a mission to revolutionize the diagnosis and treatment of cardiovascular diseases. We are a medical company backed by 28 world-class cardiologists and led by our expert Scientific Board with decades of experience in daily patient care, clinical research, and medical devices. The results of our research are implemented, developed, certified, and brought to market by our 50+ strong interdisciplinary team of physicians, data scientists, AI experts, software engineers, regulatory specialists, and commercial teams.

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