Scientific Board

PMcardio's AI is built and validated under the guidance of an international Scientific Board — interventional cardiologists, electrophysiologists, heart-failure specialists, and emergency physicians who shape clinical practice worldwide. They define the clinical standards our AI ECG models are held to, oversee independent validation, and keep PMcardio aligned with the latest guidelines for cardiovascular care.

Together, the board spans the institutions and trials defining modern cardiology — from the OMI paradigm and the Midwest STEMI Consortium to ESC and EAPCI guideline committees.


How the board shapes PMcardio

From bedside expertise 
to clinical-grade AI

Every PMcardio AI ECG Module is developed against the clinical frameworks our board members helped create, and is validated in independent, peer-reviewed studies. The board is organized around the clinical pathways PMcardio serves, so each model is governed by the specialists who define care in that area.

Acute Coronary Syndrome (ACS)

Guides the Queen of Hearts™ STEMI/OMI model — built on the Occlusion Myocardial Infarction paradigm to detect heart attacks that classic STEMI criteria miss.

Heart Failure & Arrhythmia

Guides LVsense™ (reduced ejection fraction) and arrhythmia detection — bringing structural and rhythm expertise to the ECG.

Electrophysiology

Oversees rhythm and conduction interpretation and the evidence behind it.

The evidence behind the board

Guidance backed by published evidence

Our board's oversight is reflected in a growing body of independent, peer-reviewed validation — including the landmark Queen of Hearts™ validation in European Heart Journal — Digital Health, the DIFOCCULT-3 randomized controlled trial presented at TCT 2025, and the ongoing multi-country AI ECG TIMI Study.

Publications

Research collaboration & real-world impact
AZORG Health System logo

In partnership with the Heart Center Aalst

Our long-standing collaboration with the Heart Center Aalst — one of Europe's leading cardiology centers, part of Belgium's AZORG Health System — pairs PMcardio's AI with world-class clinical expertise. After one year of system-wide deployment across six AZORG hospitals, the results are measurable:

Publications

  • 32,800+ECGs analyzed in one year
  • 500+heart attacks identified
  • 48 minaverage faster treatment — up to 6 hours earlier in complex cases
  • 64-minmedian time to treatment, within ESC guidelines
  • +50%improvement in guideline compliance
  • 350+clinicians supported each month

"PMcardio fundamentally changed how we coordinate acute cardiac care across our entire network."

Eric Wyffels, Chair and Managing Director of Heart Center Aalst
Eric Wyffels, MD MPH eMBA Chair & Managing Director
Heart Center Aalst (AZORG Health System)
Powerful Medical and Heart Center Aalst team outside the AZORG hospital in Belgium
Patient Pathway case study video still by Powerful Medical and Heart Center Aalst
Play case study video
FAQ

Frequently Asked Questions

What is PMcardio?

PMcardio offers CE-certified AI ECG Models that read ECGs and offers a comprehensive assessment of 50+ cardiac findings. Clinically validated in 25+ peer-reviewed studies and trusted by over 120,000 clinicians worldwide, it delivers rapid, expert-level interpretations, empowering emergency physicians, GPs, nurses, paramedics, and cardiologists to act with confidence at the point of care. Certain AI ECG Modules are CE-marked medical devices under EU MDR and only certified for marketing in the European Union and the United Kingdom. PMcardio technology has not yet been cleared by the US Food and Drug Administration (FDA) for marketing in the USA. Not all modules and functionality of the PMcardio platform may be available in your region.

Is it safe to upload ECG images to PMcardio?

Yes, your encrypted data never leaves your region. PMcardio is fully GDPR and HIPAA compliant and adheres to the strictest regulatory and security frameworks, including SOC 2 Type II and ISO 27001 certifications. For a detailed overview of compliance, data protection practices, and security protocols, [visit the Trust Center](https://trust.powerfulmedical.com/).

Is PMcardio clinically validated?

Yes, PMcardio's AI ECG Modules has been rigorously validated in more than 25 independent, peer-reviewed clinical studies. Across these studies, PMcardio AI ECG interpretation outperformed standard-of-care methods, delivering: - **2x sensitivity for early STEMI detection** (often on the very first ECG) - **Up to 92% fewer false-positive cath-lab activations** (JACC: Cardiovascular Interventions, presented at TCT) - **Identifies atrial fibrillation (and other arrhythmias) with 98.3% accuracy** — on par with board-certified cardiologists For more information, the latest published evidence, and ongoing RCTs, please [visit the Research page](/research).

Which ECG formats does PMcardio accept?

PMcardio accepts any commercially available 12-lead ECG — whether a single-page image or a multi-page report. For a reliable read, three things matter: the ECG must be on standard ECG graph paper (the grid where every five 1 mm squares form a heavier 5 mm square); the whole tracing must appear on one continuous grid, not split across intersecting grids; and the image should contain only that ECG's leads, with no leads from other ECGs in the frame. Fewer-lead recordings (1-, 3-, or 6-lead) are not supported.

What ECG abnormalities can PMcardio detect?

PMcardio's AI-powered ECG algorithms recognize 50+ distinct findings across four major categories: - **Rhythms & arrhythmias:** Atrial fibrillation/flutter, supraventricular or ventricular tachycardia, sinus bradycardia/tachycardia - **Conduction disorders:** Left/right bundle-branch block, second- and third-degree AV block - **Ischaemia & infarction:** Acute ST-elevation myocardial infarction (STEMI) and STEMI equivalents - **ECG measurements:** QTc, PR, QRS and nine additional measurements Looking for the full, continuously updated list? Navigate to the [Full List of ECG Findings Detected by PMcardio AI](/supported-diagnoses/).

Is PMcardio just another AI chatbot like ChatGPT or Perplexity?

No. PMcardio's AI ECG Models are deterministic, CE-certified medical devices purpose-built for ECG interpretation, not a conversational large language model (LLM). - **Zero hallucinations:** The same ECG file always returns the same diagnosis. - **Evidence-based training:** Fixed model weights are derived from **4 million+ clinically labelled ECGs** with matched patient outcomes. - **Independent proof:** Performance has been independently validated in **25+ peer-reviewed validation studies** across Europe and the U.S. - **Regulatory oversight:** Post-market surveillance and quality-management systems ensure ongoing compliance with Medical Device Regulation. [Learn more](/blog/ecg-interpretation-tools-compared-why-pmcardio-stands-out/) about how PMcardio compares to AI chatbots like ChatGPT.

Is PMcardio more accurate than automated ECG machine reads?

Yes. In six peer-reviewed studies, PMcardio AI ECG Models have demonstrated up to 2x higher accuracy than conventional ECG algorithms used in standard ECG machines (e.g., GE Marquette 12SL, Philips, Glasgow Algorithm). [Learn more](/blog/ecg-interpretation-tools-compared-why-pmcardio-stands-out/) about how PMcardio compares to Conventional ECG Algorithms.

Is PMcardio free?

Yes. Start with a Free Plan that lets you analyze **up to 5 ECGs per month at no cost**. When you need more reports and advanced Pro features, you can upgrade to a paid subscription with: - **Larger monthly ECG quota:** run as many studies as your workflow demands. - **AI explainability for STEMI:** colour-coded highlights show the waveform segments driving each positive diagnosis. - **12 validated interval measurements:** instant PR, QRS, QTc intervals and more. - **30-day report history:** revisit, download, or share any ECG analysed in the past month. **Try PMcardio for free — available now on the [Apple App Store](https://apps.apple.com/app/pmcardio-ecg-analysis/id1640037895) and [Google Play Store](https://play.google.com/store/apps/details?id=com.powerfulmedical.pmcardio).**

How do I get started?

PMcardio is available on iOS, Android, and web. Start free with 5 ECGs/month — no credit card required. Download it on the [Apple App Store](https://apps.apple.com/app/pmcardio-ecg-analysis/id1640037895) or [Google Play](https://play.google.com/store/apps/details?id=com.powerfulmedical.pmcardio). Certain AI ECG Modules are CE-marked medical devices under EU MDR and only certified for marketing in the European Union and the United Kingdom. PMcardio technology has not yet been cleared by the US Food and Drug Administration (FDA) for marketing in the USA. Not all modules and functionality of the PMcardio platform may be available in your region.

Prof. Dr. Timothy D. Henry

ACS Pathway Advisor

Leading expert in interventional cardiology and STEMI treatment. Co-founder and principal investigator of the Midwest STEMI Consortium, a registry of more than 20,000 consecutive STEMI activations. Presenting author for the TCT 2025 Late-Breaking Clinical Science on Queen of Hearts.

Prof. Dr. Timothy D. Henry

Prof. Dr. Jozef Bartunek, PhD

Co-Founder and Chair, Clinical Strategy and Advisory Board

Interventional cardiologist and Co-director of the Cardiovascular Center in Aalst, Belgium — one of the world's leading heart centers. A Fogarty International NIH Fellow at Harvard Medical School and visiting Professor of Medicine at Catholic University Leuven, he has authored more than 240 peer-reviewed publications in heart failure and structural heart disease, and anchors Powerful Medical's clinical and research strategy.

Prof. Dr. Jozef Bartunek, PhD

Prof. Dr. Marco Valgimigli, PhD

ACS Pathway Advisor

Head of Cardiology at Cardiocentro Ticino and Principal Investigator of the TITAN-OMI randomized controlled trial. His research has shaped both European and US clinical practice guidelines on coronary stents, antithrombotic therapy, and vascular access.

Prof. Dr. Marco Valgimigli, PhD

Dr. Scott Sharkey

ACS Pathway Advisor

Chief Medical Officer of the Minneapolis Heart Institute Foundation and practicing cardiologist at Allina Health Minneapolis Heart Institute. Co-founder of the STEMI Midwest consortium and Takotsubo cardiomyopathy research program and a widely published clinical investigator in STEMI care.

Dr. Scott Sharkey

Prof. Dr. Emanuele Barbato, PhD

ACS Pathway Advisor

Interventional cardiologist specializing in coronary artery disease and coronary physiology. Acting president of the European Association of Percutaneous Cardiovascular Interventions (EAPCI) and contributor to the clinical practice guidelines for STEMI care.

Prof. Dr. Emanuele Barbato, PhD

Prof. Dr. Stephen W. Smith

ACS Pathway Advisor

Faculty physician in Emergency Medicine at Hennepin County Medical Center and Professor of Emergency Medicine at the University of Minnesota. Co-inventor of the OMI paradigm and editor of Dr. Smith's ECG Blog, the most-visited US-based ECG interpretation blog.

Prof. Dr. Stephen W. Smith

Dr. Suzanne J. Baron, MSc

ACS Pathway Advisor

Director of Interventional Cardiology Research at Massachusetts General Hospital. Holds a Master's degree in health economics from Harvard School of Public Health. Expert in cardiovascular device impact on healthcare costs and patient-reported outcomes.

Dr. Suzanne J. Baron, MSc

Prof. Dr. Leor Perl

ACS Pathway Advisor

Director of Complex Cardiac Interventions and Chief Innovation Officer at Rabin Medical Center. Graduate of the Stanford Biodesign Program.

Prof. Dr. Leor Perl

Prof. Dr. Robert Hatala, PhD

Co-founder & Chief Scientist, Powerful Medical

Head of the Arrhythmia and Pacing department at the National Institute of Cardiovascular Diseases in Slovakia. More than 150 publications and 10,000 citations. Contributor to ESC clinical practice guidelines and executive editor of the European Heart Journal since 2020.

Prof. Dr. Robert Hatala, PhD

Dr. Ward Heggermont, PhD

HF and Arrhythmia Pathways Advisor

Co-director at the Cardiovascular Center of Aalst Hospital, specializing in heart failure. Research focus at the intersection of cardiology, virology, and metabolism.

Dr. Ward Heggermont, PhD

Dr. Martin Penicka, PhD

HF and Arrhythmia Pathways Advisor

Cardiologist at the Cardiac Center Aalst since 2009, specializing in non-invasive imaging and valvular disease. Fellow of the European Society of Cardiology (FESC) and the European Association of Cardiovascular Imaging (FEACVI).

Dr. Martin Penicka, PhD

Dr. Tom De Potter

HF and Arrhythmia Pathways Advisor

Cardiologist specializing in Pacemaker Device Therapy and Electrophysiology. Leads the electrophysiology unit at the Heart Center in Aalst, holds an executive board position at the European Heart Academy, and serves as EHRA scientific program committee co-chair.

Dr. Tom De Potter